Essay on Parkinsons Disease - 4145 Words

Parkinson’s Disease (from hereon PD) is an extrapyramidal disorder characterized primarily by massive idiopathic degeneration of dopaminergic neurons in the substantia nigra, resulting in greatly decreased levels of dopamine in the striatum. The diagnosis, which is essentially a clinical judgment due to the lack, thus far of a simple diagnostic test, has historically been on the basis of the presence of at least two of the three main features of PD: bradykinesia (or akinesia or hypokinesia), rigidity, and resting tremor. In addition to these symptoms, most PD patients also show postural disturbances, impaired righting reflexes, and abnormal ocular movements. The extent of the disease and its symptoms can be quantified by one of a few†¦show more content†¦A technique has been found that reveals a rhythmic 4-6 Hz tremor immediately following voluntary movements even in those PD patients that do not show clinically obvious resting tremor, indicating that even in PD patie nts without observable tremor, the abnormal mechanisms for generating the pathological 4-6 Hz tremor exist, but for some unknown reason do not normally come into play. Tremor analysis of this type may be of use in strengthening uncertain diagnoses of PD, or possibly in providing an early indication of the onset of the disease As to the cause of the tremor, it has generally been postulated to result from oscillatory activity of thalamocortical loops, independent of actual basal ganglia circuitry. Recent findings involving the subthalamic nucleus, however, suggest that the basal ganglia may actually participate directly in tremor production in PD. The rigidity seen in PD is different than UMN lesion rigidity in that it is present to an equal extent in opposing muscle groups. When resting tremor is also present, the rigidity can be felt as resistance to passive muscle movement, which is overcome as a series of jerks, called cogwheel rigidity. When tremor is not observable the rigidity is referred to as plastic rigidity. Bradykinesia or hypokinesia refers to the difficulty in initiating new movements. Once initiated, the movements are slow and deliberate, and movements such as swinging of the arms duringShow MoreRelatedThe Parkinsons Disease1596 Words   |  6 PagesMany people around the world today suffer from Parkinson’s disease and other movement disorders. A movement disorder is a disorder impairing the speed, fluency, quality, and ease of movement. There are many types of movement disorders such as impaired fluency and speed of movement (dyskinesia), excessive movements (hyperkinesia), and slurred movements (hypokinesia). Some types of movement disorders are ataxia, a lack of coordination, Huntingtons disease, multiple system atrophies, myoclonus, briefRead MoreThe Parkinsons Disease761 Words   |  3 PagesMathur states that â€Å"Genetics loads the gun, environment pulls the trigger† (Mathur). Parkinson’s Disease (PD) exhibits this pattern, with the vast majority of PD cases being idiopathic, likely the result of combined genetic and environmental factors. While many researchers previously sought symptom-specific treatment, recent breakthroughs open the door for the discovery of genetic and environmental causes so that disease prevention, and even reversal, emerge as viable possibilities. Recent research demonstratesRead More Parkinsons Disease Essay1764 Words   |  8 PagesParkinson’s disease (PD) is a striatal dopamine deficiency disorder as a consequence of neuronal loss in the substania nigra. It is named after James Parkinson, a British apothecary, who first fully documented its physical signs in 1817. Since then, significant advances have been made in our understanding of characteristic pathophysiology as well as in the medical treatment of different stages of PD. An overview of condition features in terms of epidemiology, manifestations, diagnosis and diseaseRead MoreParkinson’s Disease Essay1446 Words   |  6 PagesParkinson’s Disease is known as one of the most common progressive and chronic neurodegenerative disorders. It belongs to a group of conditions known as movement disorders. Parkinson disease is a component of hypokinetic disorder because it causes a decreased in bodily movement. It affects people who are usually over the age of 50. It can i mpair an individual motor as well as non-motor function. Some of the primary symptoms of Parkinson’s disease are characterized by tremors or trembling in handsRead More Parkinsons Disease Essay1642 Words   |  7 PagesParkinsons Disease Parkinson’s Disease (PD), the shaking palsy first described by James Parkinson in 1817, is a progressive neurodegenerative disorder which affects in upwards of 1.5 million Americans. The disease begins to occur around age 40 and has incidence with patient age. One survey found that PD may affect 1% of the population over 60. Incidence seems to be more prominent in men, and tends to progress to incapacity and death over one or two decades. Clinical diagnosis of PD isRead MoreEssay on Parkinson’s Disease1305 Words   |  6 PagesParkinson’s Disease (PD) is a chronic neurological disease that effects about 329 per 100,000 people in the US. The average onset of this disease usually is for people over the age of 50, with the baby boomers getting older there may be an increase in this disease, as much as 9 million people worldwide. (Pawha 2010) Etiology The disease happens when the cells in the brain are damaged or stop-producing Dopamine, which helps with muscle movement, thus leaves those patients unable to control theirRead MoreParkinson’s Disease Essay1260 Words   |  6 PagesParkinson’s Disease Parkinson’s Disease (PD), known for its degenerative abilities and debilitating affects, is an illness that affects approximately 1 million Americans. The cause of this disease has not been pinpointed, although strides have been made towards a cure. As our elderly population increases, so does our overwhelming need to find a suitable cure that may one day eliminate this disease. Concepts of PD After watching the video: My father, My Brother, and Me, viewable at www.pbsRead MoreParkinsons Disease Essay1504 Words   |  7 Pages Parkinsons Disease Parkinsons is an idiopathic, multifactorial neurodegenerative disease that attacks neurotransmitters in the brain called dopamine. Dopamine is concentrated in a specific area of the brain called the substantia nigra. The neurotransmitter dopamine is a chemical that regulates muscle movement and emotion. Dopamine is responsible for relaying messages between the substantia nigra and other parts of the brain to control body movement. The death of these neurotransmitters affectsRead MoreEssay Parkinsons Disease3763 Words   |  16 PagesParkinsons Disease In 1817, James Parkinson published his famous treatise: An Essay on the Shaking Palsy, describing the symptoms which now collectively bear his name. Although many scientists before his time had described various aspects of motor dysfunction (ataxia, paralysis, tremor) Parkinson was the first to collect them into a common syndrome; one which he believed formed a distinctive condition. His sixty-six page essay contained five chapters describing symptoms, differential diagnosesRead MoreParkinsons Disease Essay784 Words   |  4 PagesDiagnosis of Parkinson’s Disease is extremely important in terms of treating the symptoms before the disease gets worse. It is common for patients with PD to have motor symptoms such as gait disorder, which comes from muscle stiffness/rigidity, bradykinesia, postural imbalance, etc. Gait disorders can generally help determine how far the neurological disorder has affected the motor function and control of the individual. Many physicians in general c linics determine if a patient has PD or if it has